9/20/2023 0 Comments Timi and leslie madison![]() ![]() ![]() In this study we aimed to identify BMI-associated variants that may have been missed by previous studies and sought to confirm previously reported associations. Variants that are rare in individuals of EA but may be more common in other ancestries, or those loci that require environmental exposures that differ by the population subgroup, exist and require approaches beyond standard GWAS in only European-based samples to be identified ( 17, 18). These studies have specifically searched for and identified common genetic variants that associate with BMI in individuals of EA and follow an additive genetic model. As of March 2012, common genetic variants in 32 human loci from genome-wide association studies (GWAS) have been reported to be associated with the body mass index (BMI) in individuals of European ancestry (EA) ( 12– 16). Although sedentary behaviors and poor nutrition certainly contribute to the pathogenesis of obesity, genetic variation also plays a role, with estimated heritability ranging from 40% to as high as 90% ( 9– 11). Obesity increases the risk of metabolic conditions such as cardiovascular diseases (CVDs) ( 4, 5), type 2 diabetes (T2D) ( 6), hyperlipidemia ( 7) as well as certain cancers ( 8). Obesity is a complex disorder affecting more than one-third of the US adult population ( 1, 2) and approximately half a billion people worldwide ( 3). These multi-ethnic meta-analyses expand our knowledge of BMI genetics. Of the 11 array-wide significant SNPs, three are associated with gene expression levels in both primary B-cells and monocytes with rs4788099 in SH2B adaptor protein 1 ( SH2B1) notably being associated with the expression of multiple genes in cis. Conditional analyses revealed two independent BMI-associated signals in BDNF and melanocortin 4 receptor ( MC4R) regions. Of 10 loci with previous evidence for BMI association represented on the IBC array, eight were replicated, with the remaining two showing nominal significance. At an array-wide significance ( P < 2.40E-06), we identify novel BMI associations in loci translocase of outer mitochondrial membrane 40 homolog (yeast) - apolipoprotein E - apolipoprotein C-I ( TOMM40-APOE-APOC1) (rs2075650, P = 2.95E-10), sterol regulatory element binding transcription factor 2 ( SREBF2, rs5996074, P = 9.43E-07) and neurotrophic tyrosine kinase, receptor, type 2 in the Phase IV meta-analysis. We used a five-phase study design: Phase I focused on meta-analysis of EA studies providing individual level genotype data Phase II performed a replication of cohorts providing summary level EA data Phase III meta-analyzed results from the first two phases associated SNPs from Phase III were used for replication in Phase IV finally in Phase V, a multi-ethnic meta-analysis of all samples from four ethnicities was performed. We used the ITMAT-Broad-Candidate Gene Association Resource (CARe) (IBC) array comprising up to 49 320 single nucleotide polymorphisms (SNPs) across ∼2100 metabolic and cardiovascular-related loci to genotype up to 108 912 individuals of European ancestry (EA), African-Americans, Hispanics and East Asians, from 46 studies, to provide additional insight into SNPs underpinning BMI. Bag Measures: 10"H x 17” W x 6.5” D and a 9.Recent genetic association studies have made progress in uncovering components of the genetic architecture of the body mass index (BMI).Inside key fob – never lose your keys again!.Water-resistant, light colored lining so you can easily see everything in your bag.Coordinated stroller straps to hang your bebe bag from your stroller.An insulated bottle tote to keep your baby's bottles warm or cool.A stylish clutch that you can use as your purse (who wants to carry a purse and a bebe bag?) with interior credit card slots and an inside zipper pocket.Our specially designed changing pad with a front mesh pocket to store your diapers, wipes or cream when you need to make a quick diaper change trip.An adjustable cross body, detachable strap so you can wear the bag hands free.The Black with Saddle Madison diaper bag comes with 6 fashionable and functional accessories so you never have to sacrifice style for functionality This stylish Teal MAdison with Cinnamon straps is made from easy to clean vegan faux leather (PVC free) and features our custom hardware in an antique brass finish. The fastest growing diaper bag in the beautiful timi & leslie line.the Madison. ![]()
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